Publications

 

  1. Hong JY, Price IR, Bai JJ, Lin H. ‘A Glycoconjugated SIRT2 Inhibitor with Aqueous Solubility Allows Structure-Based Design of SIRT2 Inhibitors.” ACS Chem Biol. Aug 2, 2019 Link
  2. Son SI, Cao J, Zhu CL, Miller SP, Lin H. “Activity-Guided Design of HDAC11-Specific Inhibitors.” ACS Chem Biol. Jul 2, 2019 Link
  3. Li M, Chiang YL, Lyssiotis CA, Teater MR, Hong JY, Shen H, Wang L, Hu J, Jing H, Chen Z, Jain N, Duy C, Mistry SJ, Cerchietti L, Cross JR, Cantley LC, Green MR, Lin H, Melnick AM. “Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis.” Cancer Cell. Jun 10, 2019 Link
  4. Zhang S, Spiegelman NA, Lin H. “Global Profiling of Sirtuin Deacylase Substrates Using a Chemical Proteomic Strategy and Validation by Fluorescent Labeling.” Methods Mol Biol. Jun 4, 2019 Link
  5. Hong JY, Cao J, Lin H. “Fluorogenic Assays for the Defatty-Acylase Activity of Sirtuins.” Methods Mol Biol. Jun 4, 2019 Link
  6. Farooqi AS, Hong JY, Cao J, Lu X, Price IR, Zhao Q, Kosciuk T, Yang M, Bai JJ, Lin H. “Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model.” J Med Chem. Apr 25, 2019 Link
  7. Latifkar A, Ling L, Hingorani A, Johansen E, Clement A, Zhang X, Hartman J, Fischbach C, Lin H, Cerione RA, Antonyak MA. “Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity.” Dev Cell. Apr 1, 2019 Link
  8. Wang H, Zeng X, Mo Y, He B, Lin H, Lin J. “Characterization of the enterobactin-specific antibodies induced by a novel enterobactin conjugate vaccine.” Appl Environ Microbiol. Mar 15, 2019 Link
  9. Kosciuk T, Wang M, Hong JY, Lin H. “Updates on the epigenetic roles of sirtuins.” Curr Opin Chem Biol. March 12, 2019 Link
  10. Cao J, Sun L, Aramsangtienchai P, Spiegelman NA, Zhang X, Huang W, Seto E, Lin H. “HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2.” PNAS. Feb 28, 2019 Link
  11. Spiegelman NA, Hong JY, Hu J, Jing H, Wang M, Price IR, Cao J, Yang M, Zhang X, Lin H. “A Small Molecule SIRT2 Inhibitor that Promotes K-Ras4a Lysine Fatty-acylation.” ChemMedChem. Feb 7, 2019 Link
  12. Wang WW, Angulo-Ibanez M, Lyu J, Kurra Y, Tong Z, Wu B, Zhang L, Sharma V, Zhou J, Lin H, Gao YQ, Li W, Chua KF, Liu WR. “A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7.” J Am Chem Soc. Jan 17, 2019 Link
  13. Zhang Y, Lin Z, Wang M, Lin H. “Selective usage of isozymes for stress response.” ACS Chem Biol. Oct 17, 2018 Link
  14. Hong JY, Zhang X, Lin H. “HPLC-Based Enzyme Assays for Sirtuins.” Methods Mol Biol. August 11, 2018 Link
  15. Dong M, Zhang Y, Lin H. “Methods for Studying the Radical SAM Enzymes in Diphthamide Biosynthesis.” Methods Enzymol. 2018 Link
  16. Spiegelman NA, Price IR, Jing H, Wang M, Yang M, Cao J, Hong JY, Zhang X, Aramsangtienchai P, Sadhukhan S, Lin H. “Direct Comparison of SIRT2 Inhibitors: Potency, Specificity, Activity-Dependent Inhibition, and On-target Anticancer Activities.” ChemMedChem. July 29 2018 Link
  17. Dong M, Zhang Y, Lin H. “Noncanonical Radical SAM Enzyme Chemistry Learned from Diphthamide Biosynthesis.” Biochemistry. 2018 Link
  18. Dong M, Kathiresan V, Fenwick MK, Torelli AT, Zhang Y, Caranto JD, Dzikovski B, Sharma A, Lancaster K, Freed J, Ealick SE, Hoffman BM, Lin H. “Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis.” Science. March 16, 2018 Link
  19. Jiang H, Zhang X, Chen X, Aramsangtienchai P, Tong Z, Lin H. “Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies.” Chem Rev. February 14, 2018 Link
  20. Zhang X, Cao J, Miller SP, Jing H, Lin H. “Comparative Nucleotide-Dependent Interactome Analysis Reveals Shared and Differential Properties of KRas4a and KRas4b.” ACS Cent Sci. January 24, 2018 Link
  21. Jing H, Zhang X, Wisner SA, Chen X, Spiegelman NA, Linder ME, Lin H. “SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a.” eLife. December 14, 2017 Link
  22. Yin X, Wu Q, Monga J, Xie E, Wang H, Wang S, Zhang H, Wang ZY, Zhou T, Shi Y, Rogers J, Lin H, Min J, Wang F. “HDAC1 Governs Iron Homeostasis Independent of Histone Deacetylation in Iron-Overload Murine Models.” Antioxidants & Redox Signaling. December 13, 2017 Link
  23. MacDonald RJ, Shrimp JH, Jiang H, Zhang L, Lin H, Yen A. “Probing the requirement for CD38 in retinoic acid-induced HL-60 cell differentiation with a small molecule dimerizer and genetic knockout.” Scientific Reports. December 12, 2017 Link
  24. Meng L, Chiang YL, Lyssiotis C, Teater M, Shen H, Wang L, Hong JY, Jin H, Duy C, Mistry C, Cerchietti L, Cross J, Cantley L, Lin H, Melnick A. “SIRT3 Is a Novel Metabolic Driver of and Therapeutic Target for Chemotherapy Resistant Dlbcls.” Blood. December 7, 2017 Link
  25. Zhang L, Lin H. “Using Clickable NAD+ Analogs to Label Substrate Proteins of PARPs.” Methods Mol Biol. July 11, 2017 Link
  26. Zhang X, Spiegelman NA, Nelson OD, Jing H, Lin H. “SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation.” eLife. April 13, 2017 Link
  27. Dong M, Horitani M, Dzikovski B, Freed JH, Ealick SE, Hoffman BM, Lin H. “Substrate-Dependent Cleavage Site Selection by Unconventional Radical S-Adenosylmethionine Enzymes in Diphthamide Biosynthesis.” J Am Chem Soc. April 6, 2017 Link
  28. Wang Y, Fung YME, Zhang W, He B, Chung MWH, Jin J, Hu J, Lin H, Hao Q. “Deacylation mechanism by SIRT2 Revealed in the 1′-SH-2′-O-Myristoyl Intermediate Structure”, Cell Chem Biol. March 16, 2017 Link
  29. Aramsangtienchai P, Spiegelman NA, Cao J, Lin H. “S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration.” J Biol Chem. Feb 14, 2017 Link
  30. Wang ZA, Kurra Y, Wang X, Zeng Y, Lee Y, Sharma V, Lin H, Dai SY, Liu WR. “A Versatile approach for site-specific lysine acetylation in proteins.” Angewandte Chemie. Jan 2, 2017 Link
  31. Tong Z, Wang M, Wang Y, Kim DD, Grenier JK, Cao J, Sadhukhan S, Hao Q, Lin H. “SIRT7 Is an RNA-Activated Protein Lysine Deacylase.” ACS Chem Biol. Nov 22, 2016 Link
  32. Lin Z, Dong M, Zhang Y, Lee EA, Lin H. “Cbr1 is a Dph3 reductase required for the tRNA wobble uridine modification”, Nat Chem Biol. Oct 3, 2016 Link
  33. Jin J, He B, Zhang X, Lin H, Wang Y. “SIRT2 Reverses 4-Oxonanoyl Lysine Modification on Histones”, J Am Chem Soc. 138, 12304-12307, 2016 Link
  34. Dong M, Horitani M, Dzikovski B, Pandelia M, Krebs C, Freed JH, Hoffman BM, Lin H. “Organometallic complex formed by an unconventional radical S-Adenosylmethionine Enzyme”, J Am Chem Soc. 138, 9755–9758, 2016 Link
  35. Sadhukhan S, Liu X, Ryu D, Nelson OD, Stupinski JA, Li Z, Chen W, Zhang S, Weiss RS, Locasale JW, Auwerx J, Lin H. “Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function.” PNAS. Apr 19, 2016 Link
  36. Aramsangtienchai P, Spiegelman NA, He B, Miller SP, Dai L, Zhao Y, Lin H. “HDAC8 catalyzes the hydrolysis of long chain fatty acyl lysine”, ACS Chem Biol. 2016 10.1021/acschembio.6b00396 Link
  37. Zhang X, Khan S, Jiang H, Antonyak MA, Chen X, Spiegelman NA, Shrimp JH, Cerione RA, Lin H. “Identifying the functional contribution of the defatty-acylase activity of SIRT6”, Nature Chemical Biology 12, 614–620,
  38. Tong Z, Wang Y, Zhang X, Kim DD, Sadhukhan S, Hao Q, Lin H. “SIRT7 Is Activated by DNA and Deacetylates Histone H3 in the Chromatin Context”, ACS Chem Biol. 11, 742-7, 2016 Link
  39. Jing H, Hu J, He B, Negrón Abril YL, Stupinski J, Weiser K, Carbonaro M, Chiang YL, Southard T, Giannakakou P, Weiss RS, Lin H. “A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity”, Cancer Cell. 29, 297-310, 2016 Link
  40. Chiang YL, Lin H. “An improved fluorogenic assay for SIRT1, SIRT2, and SIRT3”, Org Biomol Chem. 14, 2186-9, 2016 Link
  41. Li Z, Kim DD, Nelson OD, Otwell AE, Richardson RE, Callister SJ, Lin H. “Molecular dissection of a putative iron reductase from Desulfotomaculum reducens MI-1”, Biochem Biophys Res Commun 467, 503-8, 2015 Link
  42. Jing H, and Lin H. “Sirtuins in Epigenetic Regulation”, Chem. Rev., 115, 2350-2375, 2015 Link
  43. Liu X, Sadhukhan S, Sun S, Wagner GR, Hirschey MD, Qi L, Lin H, Locasale JW, “High resolution metabolomics with acyl-CoA profiling reveals widespread remodeling in response to diet.” Mol. Cell. Proteomics 2015, mcp.M114.044859 Link
  44. Teng YB, Jing H, Aramsangtienchai P, He B, Khan S, Hu J, Lin H, Hao Q, “Efficient demyristoylase activity of SIRT2 revealed by kinetic and structural studies.” Sci. Rep. 5, 8529, 2015. Link
  45. Otwell AE, Sherwood RW, Zhang S, Nelson OD, Li Z, Lin H, Callister SJ, Richardson RE, “Identification of proteins capable of metal reduction from the proteome of the Gram-positive bacterium Desulfotomaculum reducens MI-1 using an NADH-based activity assay.” Environ. Microbiol. 2014 Link
  46. He B, Hu J,   Zhang X, and Lin H. “Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors”, Org. Biomol. Chem., 12, 7498-7502, 2014 Link
  47. Lin Z, Su X, Chen W, Ci B, Zhang S, Lin H. Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis. J Am Chem Soc. 2014 Link
  48. Shrimp JH, Hu J, Dong M, Wang BS, Macdonald RJ, Jiang H, Hao Q, Yen A, Lin H. Revealing CD38 Cellular Localization Using a Cell Permeable, Mechanism-Based Fluorescent Small Molecule Probe. J Am Chem Soc. 2014 Link
  49. Dong M, Su X, Dzikovski B, Dando EE, Zhu X, Du J, Freed JH, Lin H. Dph3 is an electron donor for dph1-dph2 in the first step of eukaryotic diphthamide biosynthesis. J Am Chem Soc. 136, 1754-7, 2014 Link
  50. G. Colak, Z. Xie, A. Zhu, L. Dai, Z. Lu, Y. Zhang, X. Wan, Y. Chen, Y.H. Cha, H. Lin, Y. Zhao, and M. Tan, “Identification of Lysine Succinylation Substrates and the Succinylation Regulatory Enzyme CobB in Escherichia coli”. Mol. Cell. Proteomics, 12, 3509-3520, 2013
  51. Yu J, Sadhukhan S, Noriega LG, Moullan N, He B, Weiss RS, Lin H, Schoonjans K, Auwerx J. “Metabolic Characterization of a Sirt5 deficient mouse model”, Sci. Rep. 3, 2806, 2013.
  52. Su X, Lin Z, Lin H. The biosynthesis and biological function of diphthamide. Crit Rev Biochem Mol Biol. 2013 Link
  53. Hu J, He B, Bhargava S, Lin H. A fluorogenic assay for screening Sirt6 modulators. Org Biomol Chem. 11, 5213-6, 2013 Link
  54. Jiang H, Khan S, Wang Y, Charron G, He B, Sebastian C, Du J, Kim R, Ge E, Mostoslavsky R, Hang HC, Hao Q, Lin H. SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature. 496, 110-3. 2013 Link
  55. Jiang H, Lin H. Labeling Substrate Proteins of Poly(ADP-ribose) Polymerases with Clickable NAD Analog. Curr Protoc Chem Biol. 4, 19-34, 2012 Link
  56. Su X, Lin Z, Chen W, Jiang H, Zhang S, Lin H. Chemogenomic approach identified yeast YLR143W as diphthamide synthetase. Proc Natl Acad Sci U S A. 109, 19983-7, 2012 Link
  57. Jiang H, Sherwood R, Zhang S, Zhu X, Liu Q, Graeff R, Kriksunov IA, Lee HC, Hao Q, Lin H. Identification of ADP-ribosylation sites of CD38 mutants by precursor ion scanning mass spectrometry. Anal Biochem. 433, 218-26. 2012 Link
  58. Zhou Y, Zhang H, He B, Du J, Lin H, Cerione RA, Hao Q. The bicyclic intermediate structure provides insights into the desuccinylation mechanism of human sirtuin 5 (SIRT5). J Biol Chem. 287, 28307-14, 2012 Link
  59. Lin H, Su X, He B. Protein lysine acylation and cysteine succination by intermediates of energy metabolism, ACS Chem Biol. 7, 947-60, 2012 Link
  60. He B, Du J, Lin H. Thiosuccinyl peptides as Sirt5-specific inhibitors, J Am Chem Soc, 134, 1922-5, 2012 Link
  61. Su X, Chen W, Lee W, Jiang H, Zhang S, Lin H. YBR246W is required for the third step of diphthamide biosynthesis, J Am Chem Soc, 134(2), 773-6, 2012 Link
  62. Zhu AY, Zhou Y, Khan S, Deitsch KW, Hao Q, Lin H. Plasmodium falciparum Sir2A preferentially hydrolyzes medium and long chain fatty acyl lysine, ACS Chem Biol. 7, 155-9, 2012 Link
  63. J. Du, Y. Zhou, X. Su, J. Yu, S. Khan, H. Jiang, J. Kim, J. Woo, J. Kim, B. Choi, B. He, W. Chen, S. Zhang, R. Cerione, J. Auwerx, Q. Hao, and H.Lin. Sirt5 is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase, Science. Vol. 334, No 6507, 806-809, 2011 Link
  64. H. Lin, “S-Adenosylmethionine-dependent alkylation reactions: When are radical reactions used?” Bioorg. Chem. 39, 161-170, 2011
  65. X. Zhu, B. Dzikovski, X. Su, A.T. Torelli, Y. Zhang, S.E. Ealick, J.H. Freed, and H. Lin. Mechanistic understanding of Pyrococcus horikoshii Dph2, a [4Fe-4S] enzyme required for diphthamide biosynthesis, Mol. BioSystems. 7, 74-81, 2011 Link
  66. J. Congleton, H. Jiang, F. Malavasi, H. Lin, A. Yen, “ATRA-induced HL-60 myeloid leukemia cell differentiation depends on the CD38 cytosolic tail needed for membrane localization, but CD38 enzymatic activity is unnecessary” Exp. Cell Res. 317, 910-919 2011
  67. X. Zhu, J. Kim, X. Su, and H. Lin. Reconstitution of diphthine synthase activity in vitro, Biochemistry. 49, 9649-9657, 2010 . Link
  68. Hong Jiang, Jun Hyun Kim, Kristine M. Frizzell, W. Lee Kraus and Hening Lin;Clickable NAD Analogues for Labeling Substrate Proteins of Poly(ADP-ribose) Polymerases, JACS. 2010Link
  69. Yang Zhang, Xuling Zhu, Andrew T. Torelli, Michael Lee, Boris Dzikovski, Rachel M. Koralewski, Eileen Wang, Jack Freed, Carsten Krebs, Steven E. Ealick & Hening Lin;Diphthamide biosynthesis requires an organic radical generated by an iron–sulphur enzyme, Nature. 465,891-896, 2010 Link
  70. Q. Liu, R. Graeff, I. A. Kriksunov, H. Jiang, B. Zhang, B. V. L. Potter, N. Oppenheimer, H. Lin, H. C. Lee, Q. Hao, “Structural Basis for Enzymatic Evolution from a Dedicated ADP-ribosyl Cyclase to a Multi- functional NAD Hydrolase”, J. Biol. Chem., 284, 27637-27645, 2009. Link
  71. H. Jiang, J. Congleton, Q. Liu, P. Merchant, F. Malavasi, H.C. Lee, Q. Hao, A. Yen, H. Lin, “Mechanism-Based Small Molecule Probes for Labeling CD38 on Live Cells”, J. Am. Chem. Soc., 131, 1658-1659 (2009) Link Highlighted in Nat. Chem. Biol. 5, 149, 2009 Link
  72. J. Du, H. Jiang, H. Lin, “Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogs and 32P-NAD”, Biochemistry 48, 2878–2890, 2009 Link
  73. Q. Liu, I.A. Kriksunov, H. Jiang, R. Graeff, H. Lin, H.C. Lee, Q. Hao,“Covalent and non-covalent intermediates of an NAD utilizing enzyme – human CD38”, Chem. Biol. 15,1068-78, 2008 Link
  74. H. Lin, J. Du, H. Jiang, “Posttranslational modifications to regulate protein function”, Wiley Encyclopedia of Chemical Biology, 2008. John Wiley & Sons, Inc. DOI: 10.1002/9780470048672. wecb467 Link
  75. H. Lin, “Nicotinamide adenine dinucleotide: beyond a redox coenzyme”, Org. Biomol. Chem., 5, 2541-2554 2007 Link