This is about the mechanism of an unconventional radical SAM enzyme involved in diphthamide biosynthesis. http://science.sciencemag.org/content/359/6381/1247 Many thanks to our collaborators, Drs. Steve Ealick, Brian Hoffman, Jack Freed, Kyle Lancaster, and people in their lab for making the work possible…
Hui and Xiaoyu’s work on K-Ras has been published in eLife and ACS Central Science. Read the news story at Cornell Chronicle. http://chemistry.cornell.edu/news/research-probes-key-proteins-role-cancer-cell-growth
The paper showed that SIRT5 is important for heart metabolism and function. Read the PNAS article or the Cornell Chronicle Story
See the article at ACS Chem. Biol.
See the Cancer Cell article and the Cornell Chronicle story.
See the OBC article online.
Congratulations to Zhewang! His paper, “Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis”, is published in JACS. This paper discovers the molecular function of Dph7 in diphthamide biosynthesis and provides a revised diphthamide biosynthesis pathway.
Congratulations to Jing and Bin! Their paper, “A fluorogenic assay for screening Sirt6 modulators”, is published in Org. Biomol. Chem.